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  1. Divine Truths from Master

    I am thankful for Your disaproval.
  2. Do you currently live in China?
  3. I think the Polish will win that race. So far, very little of what the CCP has said can be believed
  4. A Polish scientist could be on the verge of a major breakthrough in the fight against coronavirus. Professor Marcin Drąg from the Wrocław University of Science and Technology and his team have cracked an enzyme which they say may be key to finding a cure. "This is the most important protein - among the many identified - that the companies looking for a super-fast diagnostic test are talking about", says Professor Marcin Drąg from the Wrocław University of Science and Technology, winner of the 2019 FNP Prize in the field of chemical and materials sciences. Professor Drąg told PAP: “If you compare the enzyme to a lock, we've got the key that opens it.” The enzyme that the team studied, SARS-CoV-2 protease, cuts the proteins present in this virus. According to Drąg: “This allows it to survive. Inhibiting the action of this enzyme immediately causes this virus to die.” He added: “If we developed a drug that would inhibit the activity of this enzyme, we would practically kill the coronavirus. This is known from the previous epidemic of coronavirus – SARS.” The enzyme was known about previously, but there were millions of possible combinations of 'keys' to it. The team from Wrocław say they have now “found the one key that matches this enzyme.” The breakthrough came after scientists at Lübeck University in Germany sent the enzyme to the Wrocław team in February. They found that there are virtually no such enzymes in humans, meaning that if drugs that target the enzyme are developed, they will harm the virus, but not the human. The publication with Professor Marcin Drąg's team's research results is still under review, but the researchers have already made their results available to scientists around the world for free. 'We have not patented this. The publication preprint is available online. This is a gift from my laboratory to anyone interested', the scientist notes. He adds that a few days after publication there is no shortage of interested parties. Teams from various parts of the world come forward with questions and cooperation proposals. Professor Drąb said: “What we have now published is some of the most important information you can have about this enzyme. It is its full substrate preference.” He added that the research shows which amino acids the enzyme can bind to in key positions. 'We can say whether they are large, small, hydrophobic or basic amino acids. We can also create a map of the most important place of this enzyme and even match to drugs that are already on the market,” he said. Chemists and companies can now use the results to create new bioactive compounds for the SARS-CoV2 virus, and develop diagnostic tests that would allow to determine whether someone has coronavirus faster. 'We are currently targeting other proteins from this virus, not just proteases. The pace of work is amazing', says Professor Marcin Drąg. Part of the success behind the quick research results was a new technology platform developed by Professor Drąg enabling the production of biologically active compounds, in particular inhibitors of proteolytic enzymes. His Hybrid Combinatorial Substrate Library (HyCoSuL) which enables scientists to design and obtain highly active and selective chemical tools, uses a wide range of amino acids (which are not found in nature) to monitor the activity of proteolytic enzymes. It can be used to develop new therapies, medicines and diagnostic methods.
  5. Everyone post some favorite quotes!

    Judge a person's level of advancement by, how often they are pulled into, meaningless confrontations.
  6. TDB Infested by imbeciles. Beware.

    Which one? QFT Quantum Field Theory QFT Question Formulation Technique QFT Quantitative Feedback Theory QFT Quoted For Truth Quit Freaking Talking Quite Freaking True
  7. TDB Infested by imbeciles. Beware.

    Not true, it sometimes goes sideways, this is true of all, (no matter how advanced) and sometimes those deadend diversions can be very long. I truly do wish you well. Take care and be well.
  8. TDB Infested by imbeciles. Beware.

    "Housewife - are millions of esoterics who do it for fun or due to new fashion, as it is new age and it is popular. Those people have low standards, they do it for entertainment, for friends, for company, i.e. like most of you here." I suspect that you are the only one at TDB that does not understand what you have just said. You may have been a Pro once. But, now you you need to recondition. I wish you well on that.
  9. TDB Infested by imbeciles. Beware.

    Are you saying that housewives cannot cultivate or are intimating that housewives are worthless?
  10. sean gone?

    Come back Sean While you are gone Our things break down With no one to repair around projects undone our lair abounds While you are gone The simple freaks with sudden shrieks and eerie creaks attack our house causing large leaks come back Sean I may be a lousy poet but, I sure have fun with it
  11. Everyone post some favorite quotes!

    "Every sentence I utter must be understood not as an affirmation, but as a question."---- Niels Bohr
  12. Think you caught Covid19, What to do

    It is a delicate balance. All we can do is try to influence others in the sublime way that lasts. The world will be in severe need of balancing. Who better than Bummers. Sure, we have all different types here but, one thing I think MOST of us (some here actually support totalitarianism) can agree on is FREEDOM! Pass it around!