voidisyinyang Posted April 4, 2008 Here's a new Harvard study demonstrating EXTERNAL QI successfully treating cancer: External Qi of Yan Xin Qigong induces G2/M arrest and apoptosis of androgen-independent prostate cancer cells by inhibiting Akt and NF-kappa B pathways Context Sensitive Lilnks Context Sensitive Lilnks more options Author(s): Yan X (Yan, Xin), Shen H (Shen, Hua), Jiang HJ (Jiang, Hongjian), Zhang CS (Zhang, Chengsheng), Hu D (Hu, Dan), Wang J (Wang, Jun), Wu XQ (Wu, Xinqi) Source: MOLECULAR AND CELLULAR BIOCHEMISTRY Volume: 310 Issue: 1-2 Pages: 227-234 Published: MAR 2008 Times Cited: 0 References: 52 Abstract: Long-term clinical observations and ongoing studies have shown antitumor effects of external Qi of Yan Xin Qigong (YXQG-EQ) that originated from traditional Chinese medicine (TCM). In order to understand the molecular mechanisms underlying the antitumor effects of YXQG-EQ, we investigate the effects of YXQG-EQ on growth and apoptosis in androgen-independent prostate cancer PC3 cells. We found that exposure to YXQG-EQ led to G2/M arrest associated with reduced cyclin B1 expression and apoptosis in PC3 cells. YXQG-EQ treatment inhibited constitutive and epidermal growth factor-induced Akt phosphorylation, basal and TNF-alpha-induced NF-kappa B activation, and downregulated anti-apoptotic Bcl-2 and Bcl-xL expression. In contrast, exposure to YXQG-EQ increased phosphorylation of Akt and Erk1/2 in human umbilical vein endothelial cells (HUVEC), and had no cytotoxic effect on either HUVEC or peripheral blood mononuclear cells (PBMC). These results indicate that YXQG-EQ has profound effects on growth and apoptosis of prostate cancer cells by targeting survival pathways including the Akt and NF-kappa B pathways. Document Type: Article Language: English Author Keywords: Akt; NF-kappa B; prostate cancer; G2; M arrest; apoptosis; external Qi of Yan Xin Qigong KeyWords Plus: SIGNALING PATHWAY; CARCINOMA-CELLS; 3-KINASE/AKT PATHWAY; TRANSCRIPTION FACTOR; CASPASE ACTIVATION; GROWTH ARREST; PC3 CELLS; BCL-XL; KINASE; SURVIVAL Addresses: Wu, XQ (reprint author), Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA 02115 USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA 02115 USA Inst Chongqing Tradit Chinese Med, Chongqing, Peoples R China New Med Sci Res Inst, New York, NY USA McMaster Univ, Hamilton, ON Canada Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA E-mail Addresses: [email protected] Publisher: SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS IDS Number: 267SE ISSN: 0300-8177 DOI: 10.1007/s11010-007-9684-2 Share this post Link to post Share on other sites
