Gluten intolerance and adrenal fatigue + other related
"I am 100% cured of my 'adrenal fatigue'. I've been very unwell for over 7 months now (bed bound in July) and been diagnosed with AF by naturopaths and via self diagnosis. Allopathic doctors either didn't know what to say or suggested the possibility of CFS (chronic fatigue syndrome).
My cure? Cutting out gluten. Yes that's right. All of my AF symptoms such as extreme fatigue, foggy brain, balance issues, low stress threshold, irritability are also symptoms of gluten intolerance! I had no idea. Check out various celiac websites.
I figured this out while travelling in China where they don't eat a lot of wheat based food. All of sudden I was feeling good until I had a big bowl of wheat noodles one day.
Three weeks has passed and I feel amazing. 100% in every way. All symptoms gone. I haven't been tested for gluten intolerance but the drastic health rebound is just too convincing to ignore. I got my life back!!!!! Now within 15 minutes of ingesting gluten I'm back to AF symptoms and the rest of the day is shot." http://www.adrenalfatiguerecovery.com/gluten-intolerance-and-adrenal-fatigue.html
Dramatic Recovery In Parkinson’s Patient with Gluten Free Diet http://www.greenmedinfo.com/blog/dramatic-recovery-parkinson-s-patient-gluten-free-diet
60 Years of Research Links Gluten Grains to Schizophrenia http://www.greenmedinfo.com/blog/60-years-research-links-gluten-grains-schizophrenia
The relationship of celiac disease to neurologic and psychiatric complications has been observed for over 40 years [7, 8]. Gluten sensitive patients also have a host of neurologic and psychiatric complications. However it is notable, based on the lack of gut involvement, that neurologic and psychiatric complications seen in gluten sensitive patients may be the prime presentation in patients suffering from this disease. Therefore gluten sensitivity may easily go unrecognized and untreated. Data suggests that up to 22% of patients with CD develop neurologic or psychiatric dysfunction , and as many as 57% of people with neurological dysfunction of unknown origin test positive for anti-gliadin antibodies . Neurologic and psychiatric complications observed with gluten-mediated immune responses include a variety of disorders. For example, a PubMed literature search (dates 1953–2011) located 162 original articles associating psychiatric and neurologic complications to celiac disease or gluten sensitivity. Thirty-six articles were located for seizure disorders, 20 articles for ataxia and cerebellar degeneration, 26 for neuropathy, 20 for schizophrenia, 14 for depression, 12 for migraine, and up to 10 articles each for anxiety disorders, attention deficit and hyperactivity disorder, autism, multiple sclerosis, myasthenia gravis, myopathy, and white matter lesions. Because the vast majority of research to date has not separated gluten sensitivity from celiac disease the true prevalence of neurologic and psychiatric complications associated with each is difficult to quantify.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641836/
Grain overload, acidosis, or grain poisoning in stock
"Grain overload is also known as acidosis or grain poisoning. It occurs when cattle, sheep or goats eat large amounts of grain, and can result in acidosis, slowing of the gut, dehydration and often death. Veterinary treatment is required for severe cases." Signs of grain overload: depressed appearance, lying down, diarrhoea, dehydration and thirst, bloating (of the left side of the abdomen), staggery or tender gait and 'sawhorse' stance, deaths." https://www.agric.wa.gov.au/feeding-nutrition/grain-overload-acidosis-or-grain-poisoning-stock
"According to a new survey, 74 percent of Americans are living with digestive symptoms like diarrhea, gas, bloating and abdominal pain. But what many people may not know is that these symptoms could indicate a more serious condition."
“Over half of them never discussed it with their doctor,” said Dr. Rashini Raj, a gastroenterologist at NYU Langone Medical Center in New York City, on behalf of AbbVie Pharmaceuticals, who commissioned the survey. “And that’s probably the most alarming part for me, because as you know, sometimes this can be a sign of a more serious underlying condition: celiac disease, Crohn’s disease, EPI or exocrine pancreatic insufficiency -- so these are symptoms you shouldn’t ignore, and unfortunately a lot of people don’t feel comfortable talking about them.”
"...protein and cereal grains are metabolized to acid and thus are acid-producing or acidogenic" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630872/
"Gluten-containing cereals are a main food staple present in the daily human diet, including wheat, barley, and rye. Gluten intake is associated with the development of celiac disease (CD) and related disorders such as diabetes mellitus type I, depression, and schizophrenia.
[The Gluten/Casein Peptides Test can determine the inability to digest wheat, rye, barley, and milk. These undigested proteins, called peptides, are associated with gastrointestinal, neurological, and neuro-developmental disorders.
The peptides from gluten and casein can react with opiate receptors in the brain, thus mimicking the effects of opiate drugs like heroin and morphine. These compounds, called neuropeptides, have been shown to react with areas of the brain's temporal lobes that are involved in speech and auditory integration. Neuropeptides also decrease the ability to feel pain and effect cognitive function.
Gliadorphin (or gluteomorphin) is a peptide derived from the wheat protein gluten. Other related grains such as rye, barley and oats also contain the sequence of amino acids found in gluten. Gliadorphin is very similar to casomorphin. Gliadorphin has been verified by mass spectrometry techniques to be present in urine samples of children with autism. Both casomorphin and gliadorphin are composed of seven amino acids, which are abbreviated below. Both caseomorphin and gliadorphin start with the beginning N-terminal sequence tyr-pro (for tyrosine and proline) and the additional pro (proline) in positions 4 and 6 of both peptides, as indicated below.
Casomorphin is a peptide derived from the milk protein casein. Casein is one of the major proteins in the milk of all mammals including cows, goats, and humans.
Dr. Reichelt in Norway, Dr. Cade at the University of Florida, and others found that urine samples from people with autism, PDD, celiac disease and schizophrenia contained high amounts of the casomorphin peptide. These peptides could also be elevated in other disorders such as chronic fatigue, fibromyalgia, and depression based on anecdotal reports of symptom remission after exclusion of wheat and dairy.] https://www.greatplainslaboratory.com/glutencasein-peptides-test/
Biochemist mother heals autistic daughter by removing gluten + dairy products
Other possible intolerances
Dairy intolerance (via casein protein)
Yeast Sensitivity (yeast proteins)
Corn allergy (zein protein)
Nightshade sensitivity (lectins)
"Prolamins are a group of plant storage proteins having a high proline content and found in the seeds of cereal grains: wheat (gliadin), barley (hordein), rye (secalin), corn (zein), sorghum (kafirin) and as a minor protein, avenin in oats."
"Prolamins are a group of plant storage proteins having a high proline content and found in the seeds of cereal grains: wheat (gliadin), barley (hordein), rye (secalin), corn (zein), sorghum (kafirin) and as a minor protein, avenin in oats. They are characterised by a high glutamine and proline content and are generally soluble only in strong alcohol solutions. Some prolamins, notably gliadin, and similar proteins found in the tribe Triticeae (see Triticeae glutens) may induce coeliac disease in genetically predisposed individuals."
Treatment with Potassium Bicarbonate Lowers Calcium Excretion and Bone Resorption in Older Men and Women ncbi.nlm.nih.gov
Fruits and vegetables are metabolized to bicarbonate and are thus alkali-producing, whereas protein and cereal grains are metabolized to acid and thus are acid-producing or acidogenic. On average, American diets tend to be acidogenic, producing an excess of about 75 mEq of acid per day (1). With aging there is a decline in renal function (2,3), a decreased capacity to excrete hydrogen ions, and a gradually increasing metabolic acidosis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630872/ Effects of Dietary Acid Load on Exercise Metabolism and Anaerobic Exercise Performance
The general strategy used for the low-PRAL diet was to increase the consumption of alkaline-promoting foods such as fruits and vegetables and to reduce the consumption of acid-promoting foods such as meats, cheeses, and grains (Welch et al., 2008).
The present study also showed that an alkaline-promoting diet (i.e. rich in fruits and vegetables and low in meat and grains) improves anaerobic exercise performance by 21%.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424466/ The positive link between bone health and fruit/vegetable consumption has been attributed to the lower renal acid load of a diet high in alkaline-forming fruit/vegetables. https://www.ncbi.nlm.nih.gov/pubmed/23827128 Acidogenic diets, commonly measured by the potential renal acid load (PRAL), have been linked with metabolic diseases including insulin resistance, hepatic dysfunction, and cardiometabolic risk. Vegan diets are linked to low dietary acid loads, but the degree of adherence to a vegan diet to demonstrate this benefit is unknown.
Since low dietary PRAL scores have been related to improve metabolic parameters, adoption of a vegan diets for several days per week should be explored as a diet strategy to lower disease risk.https://www.ncbi.nlm.nih.gov/pubmed/28677099 The vegan gut profile appears to be unique in several characteristics, including a reduced abundance of pathobionts and a greater abundance of protective species. Reduced levels of inflammation may be the key feature linking the vegan gut microbiota with protective health effects. https://www.ncbi.nlm.nih.gov/pubmed/25365383 The main finding of the present study is that diets resulting in a low systemic acid load (low PRAL) are associated with the attainment of a higher respiratory exchange ratio at the end of maximal-intensity treadmill exercise tests (∼1.20 vs. 1.14). As a result, individuals who habitually consume low PRAL diets might achieve the RER ≥ 1.10 criterion for a “true” VO2max at submaximal exercise intensities and VO2max would be underestimated if the test stopped when RER reached 1.10. Alternatively, individuals consuming an acid-promoting diet, which is common in the United States (19), would be less likely to achieve the true VO2max criterion of RER ≥ 1.10.
In conclusion, dietary qualities that result in a low systemic acid load (i.e. alkaline diets) are associated with the attainment of higher peak values for respiratory exchange ratio during maximal-intensity exercise testing. Such diets would typically be very rich in vegetables and fruits and low in meats, grains, and dairy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729016/